The project will create 600 construction jobs over the course of the build, with a view to having the first phase of the development operational by the third quarter of 2027.
Around 100 science, engineering, and technology roles are also expected to be created with the facility.
In December 2023, Kerry County Council granted a ten-year planning permission to Astellas to build the facility at the Kerry Technology Park in Dromtacker, Tralee.
The statutory timeframe for an appeal to be lodged against the granting of permission for the development has now passed, with no appeals lodged.
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A ceremony to mark the breaking of the ground was attended by Sisk, Astellas, Minister for Enterprise, Trade and Employment Simon Coveney and Minister for Education Norma Foley.
Donal McCarthy, COO, Data, Life Sciences & Tech, Sisk said: "Sisk is delighted to be appointed as Construction Manager for Astellas in Co. Kerry. We look forward to beginning construction works on site and working with key local stakeholders and supply chain partners to deliver a sustainable building and leaving a lasting legacy in Tralee and the wider community."
Louis Collins, Executive Director, Kerry Operations, at Astellas, said: "We are pleased to announce that we have awarded the construction management contract for Astellas' new facility in Tralee, Ireland to Sisk. This marks an important milestone in our commitment to expanding our production capacity and capabilities. We're looking forward to working with Sisk to bring this project to life and contribute to our global mission of ensuring a stable supply of high-quality medicines to patients worldwide. We look forward to commencing work on this exciting project in the coming weeks."
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