The application by The Hill Partnership proposes a mix of 70 industrial and business units, a retail foodstore, 14 residential units and associated landscaping on the 15 hectare site.
This is an Article 31 planning application meaning that it is of such significance that the final decision rests with the Minister.
Mr Durkan said: "This will be an economic boost for the area and will bring many jobs. It will also regenerate and enhance part of the Newry Canal that runs through the site, making it more accessible to the public.
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"Newry city centre is recognised as a strong shopping centre that benefits from its close proximity to the Republic of Ireland. After careful consideration I am satisfied that the strength of the city centre and the strong retail offering available, means that it can compete with this proposal and can continue to provide a wide range of shopping facilities for the people of Newry and the wider rural area.
"In planning terms this proposal conforms to the requirements of the Newry and Mourne Area Plan 2015 which earmarked this site for light industrial and residential development. The proposals include significant landscape improvements and measures to ensure the long term protection of the Spring Hill Rath, a scheduled monument."
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